Schiff bases are active against a wide range of organisms since they play an important role in living organisms, such as decarboxylation, transamination and C-C bond cleavage. Decarboxylation and transamination are of importance in the biosynthesis of hormones, neurotransmitters and pigments.
The chemistry of polymer-based macromolecules including Schiff bases has been receiving significant attention as one of the promising immobilization alternatives for biopolymer biosensors in various industry areas. Furthermore, the coordinating ability of the metal within the polymer-based macromolecules permits these materials to act as sensors, particularly, although studies on enzyme immobilization of the polymer-based macromolecules including metal atoms (Si, Se, etc.) on transition metal does not show this, In fact, polymer attached metals which have a coordination capability which may bond with -NH and -COOH groups of the enzyme. Work is becoming ever more diverse on this issue, On the other hand, it is exciting to synthesize the various ligands and complexes because, ligands and complexes that include sulfur and nitrogen have wide applications for the synthesis of drugs, therefore, there is considerable interest in the synthesis and characterization of these compounds.
As we know, drug resistances against antibacterial agents may be a problem in their use for medical purpose. The problem may be overcome by the preparation of metal complexes, using a process of chelation with the coordination of transition metal ions.
Schiff bases have N atoms as their basic elements. Schiff base derivatives containing donor atom can act as good chelating agents for the transition of metal ions.
Research shows that, Schiff bases and their metal complexes have been widely studied due to their import antiparasitic, fungicidal-bactericidal, and anticancer properties.