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BCH00026 - THE EFFECT OF SILVER NANOPARTICLE ON HEAMATOLOGICAL PARAMETERS AND LIPID PROFILE OF MALE WISTAR RATS


ABSTRACT

Silver nanoparticle are today one of the most commonly used nanoparticle both in everyday life, and in research laboratories. The total number of rat (n =28) were randomly divided into 4 groups of 7 J each. Group 1 were allowed free access to pelletized feed and distilled water only serves as positive control, group 2 animal were exposed to 300 and 500ppm AgNP. After 8 week of exposure, blood was colled via cardiac puncture under light anaesthesia, heart and brain were also harvested for biochemical analysis.

Lipid profile was determined spectrophotochemically, liver, brain and heart histoarchitecture was also study using histochemical stains.

Increase plasma cholesterol, triglyceride are phospholipid concentration was the hallmark of the exposure to both dose of AgNP. Meawhile the treatment seem to have no significant effect on phospholipid and HDL-C.

However, liver histology of the exposed group showed alteration in the histological profile when compared with that of the animals in the positive control group.

In conclusion, sub-chronic exposure to silver nanoparticle through drinking is associated with lipotoxic and non-lipotoxic perturbation in lipid metabolism.