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ANA00264- EFFECT OF VIRGIN COCONUT OIL ON THE TESTES OF ADULT MALE RABBITS


CHAPTER ONE

1.0       INTRODUCTION

Coconut oil, or copra oil, is an edible oil extracted from the kernel or meat of mature coconuts harvested from the coconut palm (Cocos nucifera). It has various applications. Because of its high saturated fat content, it is slow to oxidize and, thus, resistant to rancidification, lasting up to six months at 24 °C (75 °F) without spoiling (Bachanova and Connors, 2016).

Coconut tree (Bachanova and Connors, 2016).

Virgin coconut oil (VCO) is extracted from fresh coconut and differs from ordinary coconut oil because it contains more biologically active components of polyphenols, tocopherols, sterols and squalene. It has captured a lot of interest due to its ability to mitigate oxidative stress-related processes via inhibition of lipid peroxidation. Reports of its improvement of semen quality (sperm counts and motility) as well as boosting serum testosterone levels have been acknowledged (Greenberg et al., 2015).

Though VCO has many therapeutic values, there are no scientific reports on its ability to mitigate testicular injuries associated with any HAART either in human and/or experimental animal model (Greenberg et al., 2015).

The extraction of VCNO from the fresh endosperm of coconut is believed to be more beneficial than usually prepared copra oil because its mode of extraction retains more biologically active components such as vitamin E and polyphenols (Greenberg et al., 2015). A recent study conducted by De Lourdes et al. (2007) showed that despite increased testosterone levels, CNO decreased the risk of prostatic cancer by significantly reducing increase in prostate: body weight ratio induced by testosterone. Though research has reported the use of CNO in a number of biological conditions, there is a dearth of literature on its use as a pro-fertility agent. This has prompted the present investigation.

VCNO has been reported to have active polyphenol compounds which have been recognized as a powerful counter measure against lipid peroxidation. However, it has been suggested that saturated fatty acids and cholesterol each independently elevate blood cholesterol and low density lipoprotein (LDL) concentrations. Hence, coconut oil because of its high saturated fatty acid composition (consists of about 90% saturated fat) is believed to elevate blood cholesterol and therefore may be atherogenic. In this context, any dietary oil that lowers LDL cholesterol and elevates HDL cholesterol is considered to have health benefits (Nagiah et al., 2015).

1.1       AIM

To check the effect of virgin coconut oil on the testes of adult male rabbit

1.2       THE OBJECTIVES OF STUDY ARE;

  1. To evaluate the effect of virgin coconut oil on the histology of testes of adult male rabbit
  2. To monitor the weight changes in the body weights and feeding patterns of the experimental animals.
  3. To check on the sperm analysis of the experimental animals